Caralluma fimbriata is also called the new Hoodia gordonii. They are both recognized as powerful appetite suppressants. Otherwise, Caralluma is recognized more effective and safe. Moreover, the african Hoodia gordonii and the whole genus Hoodia are threatened with extinction due to international trade and strong demand. Caralluma fimbriata is a traditional Indian “famine food” with no history of adverse effects.
Caralluma fimbriata is a succulent plant that has been eaten in rural India for centuries, raw, as a vegetable. This plant is also used for its ability to suppress appetite and increase stamina. Indian tribals chew chunks of Caralluma fimbriata to suppress hunger when on a day’s hunt.
The Caralluma burns fat and calories by inhibiting the activity of different enzymes. Caralluma fimbriata contains pregnane glycosides which are believed to block the activity of citrate lyase. By blocking this enzyme, Caralluma fimbriata blocks the formation of fat by the body.
Caralluma fimbriata also blocks another enzyme called Malonyl Coenzyme A. By blocking this enzyme, fat formation is also blocked and the body is forced to burn its fat reserves.
Caralluma fimbriata has been clinically demonstrated to suppress appetite and stop hunger pangs in patients. It is believed that the pregnane glycosides in CaraIIuma fimbriata inhibit the hunger sensory mechanism of the hypothalamus.
In studies, patients on Caralluma report feeling more energetic and have gained lean muscle mass, while losing fat.
Caralluma not only inhibits fat synthesis but it also increases the burning of fat. This makes more energy available to the body and makes the patient more active and lively.
Caralluma fimbriata extract is well-tolerated, and has shown long safety record with little, if any, side effects (in studies).
Excess adipose tissue functions as an endocrine organ, producing bioactive molecules such as Il-6, TNF-alpha, and PAF-1 which are implicated in many disease states including diabetes and atherosclerosis. It also produces the peptide hormone leptin, which transmits a satiety signal to the hypothalamus. In obesity, the commonly found high leptin levels are not associated with appetite suppression, giving rise to the concept of central leptin resistance or insensitivity. Restoring leptin sensitivity and hypothalamic appetite control presents an exciting new target in obesity management.
In clinical trials the Caralluma fimbriata extract could reduce serum leptin concentration. On the other hand, C. extract reduces the synthesis of appetite stimulating hormone, ghrelin.
C.fimbriata has also antiatherosclerotic properties. In a study from 2010, demonstrated for the first time that Caralluma has other health-protective effects, namely, preventing the accumulation of lipids in the intima of the thoracic aorta, which is connected with the Caralluma extract’s antioxidant and anti-inflammatory effects.
It should be noted that C. fimbriata extract ’s effects are dose-dependent, and Caralluma products may contain different amounts of C. extract.-Source: J Nutr Metab. 2010;2010:285301. Epub 2010 Dec 28., www.fda.gov http://www.fda.gov/ohrms/dockets/dockets/95s0316/95s-0316-rpt0252-08-exhibit-02-vol184.pdf, fotó:wikimedia